The shrine boasts a history of 2,000 years and has long been the object of worship, as it is listed as a Meishin-taisha in the Engi-shiki family of shrines.
It is said that the shrine was originally located at the summit of Mt. Amatsu-take on the Aizu Plateau, and was repeatedly relocated to Mt. Hakaseyama and Mt. Myojingatake, and in the 13th year of Emperor Kinmei (522), the shrine was moved to Takata-nanbara, and in the 21st year of the same Emperor (530), the shrine was moved to its present location.
According to legend, the shrine was named Aizu (Aizu) because its deities, Ohiko-no-mikoto and Takenunakawawawake-no-mikoto, met each other, and the shrine is also the head shrine of Aizu, Oshu-ninomiya, and Iwashiro-no-ichimiya.
The mikoshi (portable shrine) donated by Moriyasu Ashina in the late Muromachi period (1336-1573) is designated as a national important cultural property, and the Hoshina family of the Aizu domain reveres the shrine and its many treasures.
The Isasumi Shrine Rice Planting Festival is one of the three oldest forms of rice planting in Fukushima Prefecture, and includes the traditional horse dance, lion chase, and rice-planting dolls.